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September 2021

Policy update coming for nonchemotherapy drug administration coding

Blue Cross Blue Shield of Michigan and Blue Care Network will be updating their policy for nonchemotherapy drug administration later this year to align with a Centers for Medicare & Medicaid Services local coverage determination for our commercial and Medicare Advantage lines of business.

Nonchemotherapy drugs should be reported with administration CPT code *96372, not chemotherapy administration code *96401. Here are the descriptions of these codes:

  • *96401: Chemotherapy administration, subcutaneous or intramuscular; non-hormonal anti-neoplastic
  • *96372: Therapeutic, prophylactic or diagnostic injection (specify substance or drug); subcutaneous or intramuscular

If the following drugs are billed with a chemotherapy administration code, the administration code will be denied.

Generic name Trade name HCPCS code
Benralizumab Fasenra™ J0517
Canakinumab Ilaris® J0638
Certolizumab pegol Cimzia® J0717
Cenosumab Prolia/Xygeva® J0897
Filgrastim (g-csf), excludes biosimilars Neupogen® J1442
Tbo-filgrastim Granix® J1447
Filgrastim-sndz, biosimilar Zarxio® Q5101
Filgrastim-aafi Nivestym® Q5110
Luspatercept-aamt Reblozyl® J0896
Mepolizumab Nucala® J2182
Octreotide acetate depot Sandotstatin LAR depot J2353
Omalizumab Xolair® J2357
Pegfilgrastim Neulasta® J2505
Pegfilgfrastim-jmdb, biosimilar Fulphila® Q5108
Pegfilgrastim-cbqv Udenyca® Q5111
Pegfilgrastim-bmez Ziextenzo® Q5120
Pegfilgrastim-apgf, biosimilar Nyvepri™ Q5122
Rilonacept Arcalyst® J2793
Tildrakizumab-asmn Ilumya™ J3245

We’ll provide the effective date of this new policy and additional information in future communications.

Appeal process

If you need to appeal a denial, follow the clinical editing appeal process. Fax one appeal at a time to avoid processing delays.

Before filing an appeal, validate that you’re using the correct administration code for billing nonchemotherapy drugs. Find examples of correct coding in this CMS article:  Billing and Coding: Complex Drug Administration Coding (A58544).**

**Blue Cross Blue Shield of Michigan doesn’t own or control this website.

No portion of this publication may be copied without the express written permission of Blue Cross Blue Shield of Michigan, except that BCBSM participating health care providers may make copies for their personal use. In no event may any portion of this publication be copied or reprinted and used for commercial purposes by any party other than BCBSM.

*CPT codes, descriptions and two-digit numeric modifiers only are copyright 2020 American Medical Association. All rights reserved.