Basic benefit and medical policy
Xembify (immune globulin subcutaneous, human-klhw)
Xembify (immune globulin subcutaneous, human-klhw) is considered established, effective Aug. 15, 2019.
Xembify (immune globulin subcutaneous, human-klhw) is considered covered when the following criteria are met:
Xembify (immune globulin subcutaneous, human-klhw) is a 20% immune globulin solution for subcutaneous injection indicated for treatment of primary humoral immunodeficiency, or PI, in patients age 2 and older.
Dosage information:
Switching from immune globulin intravenous (human), 10% (IVIG) to Xembify (immune globulin subcutaneous, human-klhw): Calculate the dose by using a dose adjustment factor (1.37)
Weekly: Begin Xembify (immune globulin subcutaneous, human-klhw) one week after last IVIG infusion.
Establish initial weekly dose by converting the monthly (or every three weeks) IVIG dose into an equivalent weekly dose and increasing it using a dose adjustment factor (1.37).
Initial weekly = Prior IVIG dose (in grams) × 1.37
dose (grams) Number of weeks between IVIG doses
Frequent dosing (two to seven times per week): Divide the calculated weekly dose by the desired number of times per week.
Switching from immune globulin subcutaneous (human) treatment (IGSC):
Weekly dose (grams) should be the same as the weekly dose of prior IGSC treatment (grams).
Pharmacy requires preauthorization of this drug.
This drug is not a benefit for URMBT.
NDCs: 13533-0810-05, 13533-0810-06, 13533-0810-10
13533-0810-11, 13533-0810-20, 13533-0810-21, 13533-0810-50 and 13533-0810-51 |